Effect of Black Grape Seed(Vitis Vinifera) Extract Consumption with Moderate-Intensity Aerobic Training on the Expression of MicroRNAs in Type 1 Diabetic Cardiac Tissue Rats

Shirani Bidabadi, Maryam; Banaei Borojeni, Jamshid; Keshavarz, Saeed; Karimi, Mohammad

doi:10.18502/ijdo.v13i4.8003

Volume 13, Issue 4 (12-2021) IJDO 2021, 13(4): 248-254 | Back to browse issues page

‎ 10.18502/ijdo.v13i4.8003

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Shirani Bidabadi M, Banaei Borojeni J, Keshavarz S, Karimi M. Effect of Black Grape Seed(Vitis Vinifera) Extract Consumption with Moderate-Intensity Aerobic Training on the Expression of MicroRNAs in Type 1 Diabetic Cardiac Tissue Rats. IJDO 2021; 13 (4) :248-254
URL: http://ijdo.ssu.ac.ir/article-1-669-en.html

Effect of Black Grape Seed(Vitis Vinifera) Extract Consumption with Moderate-Intensity Aerobic Training on the Expression of MicroRNAs in Type 1 Diabetic Cardiac Tissue Rats

Maryam Shirani Bidabadi

, Jamshid Banaei Borojeni ^*

, Saeed Keshavarz

, Mohammad Karimi

Sports Medicine Research Center, Najafabad Branch, Islamic Azad University, Najafabad, Iran.

Abstract: (1111 Views)

Objective: This study aimed to evaluate the effect of consuming grape seed extract with moderate-intensity aerobic training on the expression of miR-126 and miR-29 in the cardiac tissue in type 1 diabetic male rats.
Materials and Methods: 40 rats with an initial weight range of 160-220 g were divided into five groups: Training + Extract, Training, Extract, Diabetic / Control, and Healthy / Control. Aerobic training program was moderate intensity and rats performed aerobic training for 60 minutes a day with the intensity 70 to 75% of maximum oxygen consumption (28 meters per minute). Grape seed extract was also administered by gavage at a dose of 40 mg/kg per day.
Results: Expression of both miRNAs in the three groups of training + extract, healthy training and control was significantly higher than the two groups of extract and diabetic control (P-value= 0.001). The difference between the three groups of training + extract, healthy training and control and also the difference between the two groups of extract and diabetic control were not significant (P-value> 0.05).
Conclusion: Aerobic training may be able to prevent cardiac disease caused by type 1 diabetes.

Keywords: Diabetes, Aerobic training, Grape Seed, miR-126, miR-29a

Full-Text [PDF 128 kb] (402 Downloads)

Type of Study: Research | Subject: Special
Received: 2021/06/17 | Accepted: 2021/10/4 | Published: 2021/11/1

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